BP102T. PHARMACEUTICAL ANALYSIS Semester 1

 

Semester I

BP102T. PHARMACEUTICAL ANALYSIS

UNIT-I

(a) Pharmaceutical analysis- Definition and scope

    i) Different techniques of analysis

    ii) Methods of expressing concentration

    iii) Primary and secondary standards.

    iv) Preparation and standardization of various molar and normal solutions- Oxalic acid, sodium             hydroxide, hydrochloric acid, sodium thiosulphate, sulphuric acid, potassium permanganate             and ceric ammonium sulphate (coming soon)

(b)Errors:  Sources of errors, types of errors, methods of minimizing errors,

        accuracy, precision and significant figures (coming soon)

(c) Pharmacopoeia, Sources of impurities in medicinal agents, limit tests.(coming soon)

UNIT-II

· Acid base titration: Theories of acid base indicators, classification of

    acid base titrations and theory involved in titrations of strong, weak, and

    very weak acids and bases, neutralization curves (coming soon)

· Non aqueous titration: Solvents, acidimetry and alkalimetry titration and

    estimation of Sodium benzoate and Ephedrine HCl (coming soon)

 

UNIT-III

· Precipitation titrations: Mohr’s method, Volhard’s, Modified

    Volhard’s, Fajans method, estimation of sodium chloride. (coming soon)

· Complexometric titration: Classification, metal ion indicators, masking

    and demasking reagents, estimation of Magnesium sulphate, and calcium

    gluconate. (coming soon)

· Gravimetry: Principle and steps involved in gravimetric analysis. Purity

    of the precipitate: co-precipitation and post precipitation, Estimation of

    barium sulphate. (coming soon)

· Basic Principles,methods and application of diazotisation titratio. (coming soon)

 

UNIT-IV

Redox titrations

    (a) Concepts of oxidation and reduction

    (b) Types of redox titrations (Principles and applications)

Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with

potassium iodate (coming soon)

 

UNIT-V

· Electrochemical methods of analysis

                 · Conductometry- Introduction, Conductivity cell, Conductometric

                      titrations, applications. (coming soon)

                · Potentiometry - Electrochemical cell, construction and working

                    of reference (Standard hydrogen, silver chloride electrode and

                    calomel electrode) and indicator electrodes (metal electrodes and

                    glass electrode), methods to determine end point of potentiometric

                    titration and applications. (coming soon)

                · Polarography - Principle, Ilkovic equation, construction and

                    working of dropping mercury electrode and rotating platinum

                    electrode, applications (coming soon)